Charité – Universitätsmedizin Berlin is Europe's largest university clinic and the oldest and most prominent hospital in Berlin, Germany. Pursuant to the order of King Frederick I of Prussia dated November 14, 1709, the Charite was originally founded in 1710 north of the Berlin city walls on the eve of the plague that had already ravaged East Prussia. After the plague saved the city, it was used as a charity hospital for the poor. The construction of the anatomical theater in 1713 marks the beginning of the medical school. In 1795, the school of Pépinière was established to train military surgeons. After the founding of the University of Berlin (now Humboldt University) in 1810, in 1828 the dean of the medical college, Christoph Wilhelm Hufeland, incorporated the Charité as a teaching hospital. Rudolf Virchow, once a student at the Nursery, worked as a procurator with the anatomist Robert Froriep, and in 1856 became director of the newly established Institute of Pathology, where he developed the cell theory.