CAR T-Cell Therapy: A Revolutionary Method in Cancer Treatment and the Best Clinics

CAR T-cell therapy is a revolutionary immunotherapy method used especially in the treatment of blood cancers. Today, this promising method in cancer treatment is successfully applied in world-renowned health centers. In this article, we will examine what CAR T-cell therapy is, how it is applied, and the leading clinics that offer this treatment in the world.

What is CAR T-Cell Therapy?

CAR T-cell therapy is a type of treatment performed by genetically modifying the T-cells of the patient's immune system. This treatment is based on the principle of returning T-cells equipped with special receptors called "chimeric antigen receptors" (CAR) that affect cancer cells to the body. CAR T-cell therapy allows effective results to be obtained especially in blood cancers such as leukemia and lymphoma.

How Does CAR T-Cell Therapy Work?

CAR T-cell therapy is a very complex treatment process that is carried out in several stages:

• T-Cell Collection: T-cells are separated from the patient's blood sample.

Genetic Modification: Special antigen receptors called CAR are added to these cells in a laboratory environment. These receptors are designed to target and destroy cancer cells.

• Cell Multiplication: Genetically modified T-cells are multiplied in a laboratory environment.

• Return to Patient: The developed CAR T-cells are given back to the patient. These cells recognize and attack cancerous cells in the body and initiate the treatment process.

This treatment offers promising results, especially in advanced cancers. However, since it is a complex process, it should be performed by experienced oncologists in special clinics.

Benefits of CAR T-Cell Therapy

• Targeted Effect: CAR T-cell therapy does not harm healthy cells by targeting cancerous cells. In this way, side effects are fewer.

• High Success Rate: It offers high success rates especially in blood cancers and has the potential to provide remission.

• Reduced Risk of Relapse: Since the treatment targets and destroys cancer cells, it reduces the risk of relapse.

Car T-Cell Therapy Side Effects

Although CAR T-cell therapy is highly effective, it may have some side effects:

• Cytokine Release Syndrome: Symptoms such as fever and low blood pressure may occur as a result of the immune system overreacting.

• Neurological Side Effects: Symptoms such as headache, confusion and seizures may be observed.

• Infection Risk: Since the immune system may weaken after treatment, the risk of infection increases.

Side effects may vary from person to person. Therefore, it is important to constantly monitor patients during the treatment process.

World-Famous Clinics Offering CAR T-Cell Therapy

World-famous clinics specializing in CAR T-cell therapy stand out with their advanced technological infrastructure and experienced oncologists. Here are the leading clinics that successfully offer CAR T-cell therapy worldwide:

1. Sheba Medical Center – Tel Aviv, Israel

• - Years in Operation: Over 70 years

• - Annual Patient Volume: 1.6 million

• - Global Ranking: 9th by Newsweek

• - Details: Recognized for innovative cancer treatments, Sheba Medical Center has a high CAR T-cell therapy success rate of 70%, making it a leading choice for patients worldwide seeking advanced cancer care.

Patient testimonials

Pedro da Silva from Portugal

“The Israeli medical team was fantastic. Dr. Abraham Avigdor, Dr. Adrien Duek, and the rest of the team were always professional, and our personal medical coordinator, Victoria, was amazing and extremely helpful. Kudos to the whole Sheba team! I wholeheartedly recommend Sheba to everyone in need of medical treatment! We constantly say this to all patients and doctors in Portugal.”

Olga from Ukraine

“Meeting with the team at Sheba made me realize that I had wasted precious time neglecting my situation. I urge anyone diagnosed with cancer to immediately find good, professional doctors who you believe in. My surgery, a complex procedure, was performed in December, by a wonderful team of doctors – Dr. Rosenblatt, Dr. Brant, and the anesthesiologist Dr. Lifshitz, who made me feel at home by speaking with me in Russian. Together, these doctors instilled in me a sense of calm and confidence.”

2. Hirslanden Klinik – Zurich, Switzerland

• - Years in Operation: 85+ years

• - Annual Patient Volume: Over 100,000

• - Global Ranking: 72nd by Newsweek

• - Details: Known for its advanced technology and high patient satisfaction, Hirslanden Klinik offers CAR T-cell therapy with a strong emphasis on precision and quality care.

3. Clínica Universidad de Navarra – Pamplona, Spain

• - Years in Operation: 60+ years

• - Annual Patient Volume: Approximately 130,000

• - Global Ranking: 80th by Newsweek

• - Details: Leading the way in cancer care, this clinic is respected for research-driven CAR T-cell therapy, prioritizing tailored treatments and patient-centered care.

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Testimonials: 

Daniel from France

“The doctor demonstrated exceptional understanding and provided top-notch care, ensuring a supportive experience throughout the treatment. I was particularly impressed with the punctuality, efficiency, and warmth of both the nursing and administrative staff, who made each interaction pleasant and seamless. Their friendliness and professionalism contributed to a truly positive healthcare experience.”

4. Samsung Medical Center – Seoul, South Korea

• Years in Operation: Over 25 years

• Annual Patient Volume: Approximately 500,000

• Global Ranking: 34th by Newsweek

• Details: As a premier center in Asia for CAR T-cell therapy, Samsung is recognized for its advanced facilities and high success rates in treating complex cancer cases.

Testimonials:

Igor from Ukraine

“My experience with cancer treatment at Samsung Medical Center was surprisingly good.The doctors and nurses were extremely attentive and caring. They provided me with all the information and support I needed during my treatment. I appreciate their work and professional approach to my case. I went through chemotherapy with nausea, as expected, but overall the experience was good.”

Ron from Israel

“I visited Samsung Medical Center to get treatment for cancer and was attended by Dr. Choi Han Yong who is not only an expert in his job but also a nice person. I am glad that I got treated by him.”

5. The Cancer Institute Hospital of JFCR – Tokyo, Japan

• Years in Operation: Over 80 years

• Annual Patient Volume: Approximately 200,000

• Global Ranking: 18th by Newsweek

• Details: Renowned for its focus on precision, JFCR is a top choice in Asia, offering CAR T-cell therapy with a high success rate and a reputation for quality.

6. King’s College Hospital (King’s Private) – London, UK

• Years in Operation: Over 170 years

• Annual Patient Volume: Approximately 750,000

• Global Ranking: 231st by Newsweek

• Details: A prestigious UK institution, King’s College is recognized for CAR T-cell therapy and personalized cancer treatments delivered by experienced specialists. More detailed information you can watch video about CAR T-cell therapy at King's College Hospital

7. King Faisal Specialist Hospital & Research Centre – Riyadh, Saudi Arabia

• Years in Operation: Over 45 years

• Annual Patient Volume: Approximately 500,000

• Global Ranking: 229th by Newsweek

• Details: KFSHRC offers state-of-the-art CAR T-cell therapy with specialized cancer teams, making it one of the Middle East’s leading cancer treatment centers.

Testimonials:

"Having been admitted to King Faisal Specialist Hospital & Research Centre, I can say the level of care was exceptional. The staff went above and beyond to ensure I was comfortable and informed."

"The empathy and support provided by the nursing staff during my treatment made a significant difference in my recovery journey."

"I appreciated the clarity with which all procedures were explained to me, allowing me to be an active participant in my treatment decisions."

"We would like to express our gratitude for the high standard of care and attention provided during our difficult time."

8. Apollo Hospitals – India (Apollo Cancer Centres)

• Years in Operation: Over 40 years

• Annual Patient Volume: Around 2 million across the network

• Testimonials: Available on Apollo’s website and global healthcare forums

• Details: Known for affordable and quality CAR T-cell therapy, Apollo Hospitals attracts international patients seeking cost-effective yet advanced cancer care.

9. The London Clinic – London, UK

• Years in Operation: Over 90 years

• Annual Patient Volume: Approximately 100,000

• Testimonials: Available on The London Clinic’s website and health service review sites

• Details: Renowned for personalized CAR T-cell therapy, The London Clinic utilizes modern techniques and comprehensive cancer care teams to deliver optimal outcomes.

10. Peter MacCallum Cancer Centre – Melbourne, Australia

• Years in Operation: Over 75 years

• Annual Patient Volume: Approximately 100,000

• Testimonials: Available on Peter MacCallum’s website and Australian health review sites

• Details: Known for excellence in cancer treatment, Peter MacCallum provides advanced CAR T-cell therapy supported by cutting-edge research and patient care.

11. Acıbadem Hospitals – Istanbul, Turkey

• Years in Operation: Over 30 years

• Annual Patient Volume: Over 200,000

• Testimonials: Accessible on Acıbadem’s official website and local review sites

• Details: Acıbadem Hospitals offer CAR T-cell therapy with advanced technology and cost-effective options, making it a leading choice for regional and international patients.

12. Harmony Cancer Institute – Shanghai, China

• Years in Operation: Over 10 years

• Annual Patient Volume: Approximately 300,000

• Testimonials: Found on Harmony Cancer Institute’s website and regional health forums

Details: This institute focuses on affordable CAR T-cell therapy with a commitment to innovation, attracting patients from China and surrounding regions.

CAR T-cell therapy stands out as a promising innovative method in cancer treatment. This treatment, which offers high success rates especially in blood cancers such as lymphoma and leukemia, is successfully applied in world-renowned healthcare centers. Hospitals such as King’s College Hospital (England), Clínica Universidad de Navarra (Spain), Samsung Medical Center (South Korea) are some of the institutions that offer CAR T-cell therapy at the highest level.